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HIF-dependent antitumorigenic effect of antioxidants in vivo
ven om det inte alltid r narkotikaklassat, omfattas det ofta av lkemedelslagstiftning
PMID: 37541528
Since asparagine synthesis depends on glutamate as a precursor, GLS inhibitors further suppress asparagine synthesis by reducing glutamine availability
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The above calculation is obviously simplistic as the rates of the two reactions will vary as a function of changes in substrate concentrations following the onset of stress, and kinetic modeling would be required to examine the question more closely
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